Expertise

The iPS cell laboratory routinely cultures human embryonic stem cells (hESCs) and human iPS cells in a standardized feeder-free mode (geltrex, Essential E8 medium). To generate new patient-specific iPS cells from primary cell cultures (e.g. fibroblast), we use a polycistronic lentiviral vector in which codon-optimized reprogramming factors (OCT4, KLF4, SOX2 and cMYC) …

Read more

The center has over a decade of experience in the genetic analysis of a variety of traits. Our expertise ranges from simple heritability and gene-by-environment interaction analyses, via advanced multivariate genetic analysis and genetic risk prediction, to complex biological pathway analyses. We integrate knowledge from classical and modern genetics, biology and bioinformat…

Read more

The center has established a variety of functional assays crucial to the study of neuronal communication in human neurons. These assays center around the question how neurons communicate in culture and how they transport information, in the form of chemical or electrical signals through and between the cells. The underlying postulate is that this communication is affected in…

Read more