Brain disorders are a major economic, societal and personal burden. Current treatments are seriously hampered by a lack of insight into disease mechanisms. After a century of limited etiological progress, the past decade has seen unprecedented advances in our understanding of the fundamental genetic architectures of brain disorders.
Recent findings from large-scale genetic studies for brain disorders have led to novel biological hypotheses about these disorders and have for the first time provided clear targets for functional follow-up studies. The mission of the iPS center is to benefit from this extraordinary new knowledge by integrating state-of-the art techniques from three complementary fields: genetics, stem cell biology and functional biology. Our research will aid in identifying novel targets for treatment of brain disorders and will greatly impact early prevention strategies.
The IPS center is part of the departments of Clinical Genetics and Pediatrics of Vumc